Table 4. . Enrichment of prefrontal cortex cis-methylation quantitative trait loci in genome-wide association study-identified variants associated with psychiatric disorders.
| Psychiatric | PFC cis-mQTLs (cases + controls) | PFC cis-mQTLs (cases) | PFC cis-mQTLs (controls) | |||
|---|---|---|---|---|---|---|
| disorders | Overlapped with GWAS SNPs | p-value | Overlapped with GWAS SNPs | p-value | Overlapped with GWAS SNPs | p-value |
| AUD | 9277 | 1.2 × 10-10 | 262 | 0.093 | 685 | 0.004 |
| SCZ | 8345 | 2.2 × 10-16 | 244 | 2.1 × 10-5 | 606 | 1.6 × 10-13 |
| BIP | 8340 | 2.2 × 10-16 | 244 | 8.7 × 10-6 | 606 | 0.008 |
| MDD | 8132 | 2.2 × 10-16 | 240 | 0.123 | 580 | 0.006 |
| ADHD | 9045 | 0.006 | 257 | 0.556 | 668 | 0.028 |
AUD: Alcohol use disorder; ADHD: Attention-deficit/hyperactivity disorder; BIP: Bipolar disorder; GWAS: Genome-wide association study; MDD: Major depressive disorder; mQTL: Methylation quantitative trait locus; PFC: Prefrontal cortex; SCZ: Schizophrenia.