Skip to main content
. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Clin Cancer Res. 2020 Apr 24;26(15):3901–3907. doi: 10.1158/1078-0432.CCR-19-1321

TABLE 1.

Dendritic Cell Subtypes

DC Type Cell Surface Markers Key Transcription Factors Primary Functions
cDC1 CD11c, MHC II, CD8α (lymphoid resident), XCR1, CLEC9a, CD103, CD141 (human), CD24 BATF3, IRF8, ID2 Cross presentation of antigens to activate CD8+ T cell mediated immunity, T-helper 1 type immune response, Secretion of IL-12, CXCL9 and CXCL10 mediated T cell recruitment
cDC2 CD11c, MHC II, CD11b, Sirpα, CD301b, CD1c (human) IRF4, RBPJ, KLF4, RELB CD4+ T cell activation, Humoral immune responses, Allergic immunity and T-helper 2 type immune response
pDC CD11clow, MHC IIlow, B220, SIGLEC-H, CD317, CLEC4C (human), CD123 TCF4 (E2-2), IRF8, RUNX1 Type 1 interferon production, Limited antigen presentation to T cells, Augmenting DC responses through interferon signals

DC = dendritic cell