Table 2. Age-Standardized Incidence, Prevalence, Mortality, and Disability-Adjusted Life-Year (DALY) Rates (per 100 000 People), for Neurological Disorders in the US in 1990 and 2017 and the Percentage Change From 1990 to 2017.
| Disease | Incidence rates (95% UI) | Prevalence (95% UI) | Mortality rates (95% UI) | DALY rates (95% UI) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1990 | 2017 | Change, % | 1990 | 2017 | Change, % | 1990 | 2017 | Change, % | 1990 | 2017 | Change, % | |
| Stroke | 137.5 (127.9 to 147.6) | 115 (106.5 to 125) | −16.3 (−19.1 to −13.8) | 1539.4 (1459 to 1623) | 1537 (1461 to 1621) | −0.2 (−3.8 to 3.3) | 42 (41.4 to 42.9) | 28.6 (27.6 to 29.5) | −32.0 (−34.5 to −29.8) | 910.4 (845.5 to 973.9) | 691.9 (624.6 to 759.3) | −24.0 (−26.9 to −21.3) |
| Alzheimer disease and other dementias | 97.2 (85 to 111) | 85.2 (77.8 to 93) | −12.4 (−19.2 to −5.2) | 542.7 (468.9 to 622.1) | 470 (429.1 to 513.8) | −13.4 (−20.6 to −5.1) | 35 (34.5 to 35.4) | 38.5 (37.7 to 39.2) | 9.8 (7.3 to 12.2) | 413.6 (389.2 to 439.7) | 418.8 (398.8 to 439.1) | 1.2 (−1.9 to 4.2) |
| Parkinson disease | 10.5 (8.7 to 12.8) | 12.9 (11.2 to 14.6) | 21.9 (8.3 to 37) | 83.5 (67.7 to 101.9) | 97 (84.5 to 108.6) | 16.2 (2.7 to 31) | 3.7 (3.6 to 4.4) | 4.9 (4 to 5.1) | 33.1 (−4.6 to 41.7) | 58.1 (53.4 to 67.9) | 72.5 (61 to 78) | 24.8 (−5.2 to 32.9) |
| Idiopathic epilepsy | 40.6 (28.7 to 52.8) | 47.6 (32.3 to 62.1) | 17.4 (−6 to 45.1) | 357.3 (252.4 to 469.5) | 411.8 (290.2 to 540.5) | 15.2 (−7.5 to 43.3) | 0.6 (0.6 to 0.6) | 0.5 (0.5 to 0.6) | −2.7 (−7.8 to 1.5) | 117.4 (76.9 to 172.7) | 123.9 (75.1 to 187.5) | 5.5 (−18.4 to 33.2) |
| Multiple sclerosis | 2.9 (2.7 to 3.2) | 3.3 (3.1 to 3.5) | 13.2 (7.3 to 18.9) | 85.1 (76.8 to 94.6) | 97.6 (91.5 to 103.7) | 14.7 (8.1 to 21.3) | 0.6 (0.6 to 0.8) | 0.8 (0.6 to 0.9) | 32.8 (−20.1 to 56.1) | 40.5 (33.7 to 47.7) | 47.2 (39.3 to 54.7) | 16.6 (−1.4 to 26.2) |
| Motor neuron disease | 1.7 (1.6 to 1.8) | 1.9 (1.8 to 2.1) | 12.5 (9.8 to 15.3) | 9 (8.1 to 10) | 9.1 (8.4 to 9.8) | 0.3 (−4.4 to 5.6) | 1.2 (1.1 to 1.2) | 1.6 (1.5 to 1.7) | 38.3 (30 to 45.6) | 35.5 (34.3 to 36.8) | 42.9 (40.7 to 44.7) | 20.9 (13.9 to 27.6) |
| Migraine | 1696 (1544 to 1836) | 1722 (1578 to 1865) | 1.6 (−0.8 to 4.2) | 19 902 (18 489 to 21 465) | 20 188 (18 678 to 21 750) | 1.4 (−0.8 to 4) | NA | NA | NA | 694.1 (443.6 to 1008) | 704.8 (446 to 1020.5) | 1.5 (−0.8 to 4) |
| Tension-type headache | 12 965 (11 495 to 14 380) | 13 014 (11 602 to 14 432) | 0.4 (−2.1 to 2.9) | 34 469 (31 156 to 38 223) | 34 642 (31 341 to 38 113) | 0.5 (−2 to 3.3) | NA | NA | NA | 96.5 (54.4 to 154.3) | 96.6 (54.4 to 154.9) | 0.1 (−1.5 to 1.9) |
| Traumatic brain injury | 402 (339 to 482) | 285 (238 to 341) | −29.1 (−32.4to −25.8) | 700 (668 to 731) | 502 (478 to 525) | −28.3 (−29.7 to −26.9) | NA | NA | NA | NA | NA | NA |
| Spinal cord injury | 30 (24 to 37) | 21 (16 to 26) | −30.5 (−34.8 to −26.2) | 879 (798 to 981) | 541 (502 to 583) | −38.5 (−43.1 to −34.0) | NA | NA | NA | NA | NA | NA |
| Brain and nervous system cancers | 5.8 (5.1 to 6.3) | 7.2 (6.6 to 8.2) | 24.1 (12.4 to 41.4) | 22.5 (20 to 24.8) | 34.2 (31.7 to 40.1) | 52.2 (36.7 to 76.5) | 3.8 (3.3 to 4.1) | 3.7 (3.3 to 4.1) | −3.4 (−9.2 to 6.8) | 131.2 (114.7 to 141.4) | 119.9 (111.2 to 138) | −8.6 (−15.5 to 5.4) |
| Meningitis | 19.4 (17 to 22.4) | 13.8 (12.2 to 15.6) | −28.7 (−32.9 to −24.4) | 41 (35.6 to 47.3) | 22.7 (20 to 25.9) | −44.8 (−47.3 to −42.3) | 1.1 (0.9 to 1.2) | 0.4 (0.4 to 0.5) | −64.4 (−67.7 to −50.3) | 64.9 (56.7 to 70) | 21.5 (19.7 to 25.7) | −66.9 (−70.1 to −55.9) |
| Encephalitis | 5 (4.9 to 5.1) | 5 (4.9 to 5.1) | −0.1 (−0.7 to 0.6) | 7.1 (4.2 to 11.1) | 6.4 (3.9 to 9.8) | −10.1 (−12 to −8.1) | 0.2 (0.2 to 0.2) | 0.2 (0.2 to 0.2) | −20.6 (−24.9 to −1.7) | 10.4 (9.2 to 11) | 7.7 (7.2 to 9.5) | −25.8 (−30.7 to −5.8) |
Abbreviations: NA, not available; UI, uncertainty interval.