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. 2020 Aug 24;126(22):4975–4983. doi: 10.1002/cncr.33112

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© 2020 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Expression of p16^INK4a is higher among survivors who receive higher intensity chemotherapy regimens. The intensity of treatment is represented by the Intensity of Treatment Rating (ITR) Scale, with 1 (IRT‐1) indicating the lowest intensity and ITR‐4 indicating the highest intensity. (A) The analyses includes all patients in the survivor cohort (mean log₂ p16 units: 7.0 [ITR‐1], 9.2 [ITR‐2], 9.6 [ITR‐3], 10.7 [ITR‐4]) and (B) exclude 11 patients who received treatment with dexrazoxane (mean log₂ p16 units: 7.0 [ITR‐1], 9.3 [ITR‐2], 9.9 [ITR‐3], 11.0 [ITR‐4]).