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. 2020 Aug 24;126(22):4975–4983. doi: 10.1002/cncr.33112

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© 2020 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Expression levels of p16^INK4a are compared between matched pretreatment and posttreatment specimens from children and adolescents who were treated for a first cancer. (A) Changes in p16 expression in the current prospective cohort are categorized according to the intensity of treatment regimen (Intensity of Treatment Rating [ITR] Scale scores are indicated from 1 [lowest] to 4 [highest]). (B) Changes in p16 expression from pretreatment to posttreatment are strongly correlated with intensity of the chemotherapy regimen. Error bars represent standard error of the mean.