Figure 3.

Time activity curves describing [⁶⁸Ga]Ga-DO3A-exendin-4 uptake in the pancreas, duodenum, visceral, and subcutaneous fat for fasting and clamp conditions in lean and obese animals. For simplicity, SE and several time intervals at the beginning of the curves are not presented. The uptake by the stomach is also not presented since it does not follow a 2-tissue compartment model. Note the absence of an effect of obesity and/or of hyperinsulinemia produced by the clamp on duodenal uptake, while obesity and hyperglycemia both reduce it. SUV, standard uptake value.