Table 1.

GLP-1r binding potential expressed as a distribution volume of specific binding (Vs expressed in mL/ccm) obtained after fitting of the [⁶⁸Ga]Ga-DO3A-VS-Cys40-exendin-4 uptake to a 2-tissue compartment model in both the fasted state and during the plateau phase of a hyperinsulinemic–euglycemic clamp

	Lean		Obese
	Fasted	Insulin	Fasted	Insulin
Pancreas	4.54±0.35	1.61±0.45*	1.49±0.47†	1.54±1.31
Duodenum	3.02±0.20	2.62±0.17	2.87±0.29	2.88±0.25
Subcutaneous fat	0.13±0.02	0.09±0.02*	0.06±0.02†	0.08±0.03
Visceral fat	0.44±0.13	0.17±0.02*	0.13±0.02†	0.08±0.03

*Difference between fasted and insulin condition in lean animals.

†Difference between lean and obese animals.

GLP-1r, glucagon like peptide-1 receptor; Vs, specific volume of distribution.