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. 2020 Nov 2;8(2):e001322. doi: 10.1136/jitc-2020-001322

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Longitudinal levels of serum ALT, AST, GGT/γGT, ALP and Bil in a patient with melanoma with severe immune checkpoint inhibitor (ICPI)-mediated hepatitis and the immunosuppressive agents used to control this induced hepatotoxicity. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Bil, bilirubin; GGT, gamma-glutamyl transferase; ULN, upper normal limit. (B) Fluorodeoxyglucose-positron emission tomography CT (April 2020) revealed abnormal hypermetabolic activity of a solitary lung lesion (maximum standardized uptake value=3.4) with concurrent hyperactive mediastinal lymphadenopathy. Red arrows highlight more clearly the only abnormal hypermetabolic lesion in the lung.