Table 2.
Pooled rate of each VCE adverse events and subgroup analysis based on VCE types
| VCE type and the rate of adverse events | VCE types | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ECE | GCE | SBCE | CCE | |||||||||
| AER, % (95% CI) | Study, n | Events/VCE, n | AER, % (95% CI) | Study, n | Events/VCE, n | AER, % (95% CI) | Study, n | Events/VCE, n | AER, % (95% CI) | Study, n | Events/VCE, n | |
| Retention | 0.11 (0.00–0.46) | 18 | 8/1622 | 0.39 (0.19–0.64) | 13 | 40/5072 | 0.93 (0.75–1.12) | 217 | 1017/74115 | 0.26 (0.00–0.77) | 26 | 22/3432 |
| Esophagus IE | 9.05 (2.43–18.88) | 10 | 103/825 | 9.06 (3.95–15.76) | 2 | 9/99 | – | – | – | – | ||
| Stomach IE | 14.47 (3.65–30.35) | 4 | 52/326 | 5.27 (0.36–14.24) | 6 | 40/3494 | 4.18 (0.00–13.89) | 2 | 11/207 | – | – | |
| Small bowel IE | – | – | 13.91 (3.40–29.51) | 5 | 174/863 | 13.17 (11.88–14.50) | 245 | 9507/62956 | 3.99 (2.51–5.75) | 21 | 136/3004 | |
| Colon IE | – | – | – | – | – | – | 19.19 (14.06–24.88) | 37 | 874/4483 | |||
| Swallow disorder | 1.76 (0.88–2.86) | 19 | 39/1741 | 0.00 (0.00–0.02) | 11 | 2/4451 | 0.85 (0.41–1.42) | 95 | 336/26021 | 0.04 (0.00–0.18) | 27 | 12/4427 |
| Aspiration | 0.00 (0.00–0.82) | 3 | 0/220 | 0.00 (0.00–0.27) | 7 | 0/641 | 0.00 (0.00–0.00) | 57 | 5/19866 | 0.00 (0.00–0.00) | 18 | 0/2671 |
| Technical failure | 1.16 (0.52–1.98) | 14 | 24/1596 | 0.20 (0.00–0.98) | 8 | 6/843 | 0.83 (0.51–1.21) | 98 | 300/31068 | 1.76 (0.76–3.06) | 26 | 66/3790 |
| Procedural adverse events | 6.48 (2.65–11.65) | 19 | 133/1695 | 0.09 (0.00–0.93) | 8 | 7/4098 | 0.00 (0.00–0.05) | 59 | 20/9378 | 0.81 (0.15–1.80) | 21 | 33/3040 |
| VCE type and the rate of adverse events | VCE types | Overall | |||||||
|---|---|---|---|---|---|---|---|---|---|
| After PCE | P value between groups | AER, % (95% CI) | Study, n | Events/VCE, n | I2, % | Egger test P value | |||
| AER, % (95% CI) | Study, n | Events/VCE, n | |||||||
| Retention | 0.09 (0.00–0.34) | 15 | 9/2501 | <.0001 | 0.73 (0.59–0.89) | 289 | 1096/86742 | 70.6 | .6063 |
| Esophagus IE | – | – | .9523 | 9.05 (3.14–17.33) | 12 | 112/924 | 92.8 | .7632 | |
| Stomach IE | – | – | .3350 | 7.69 (2.45–15.21) | 12 | 103/4027 | 95.5 | .0017 | |
| Small bowel IE | 3.79 (0.12–11.08) | 7 | 85/1268 | < .0001 | 12.08 (10.89–13.32) | 278 | 9902/68091 | 95.6 | .1315 |
| Colon IE | – | – | – | 19.19 (14.06–24.88) | 37 | 874/4483 | 95.2 | .1393 | |
| Swallow disorder | 7.80 (0.00–26.93) | 3 | 37/630 | < .0001 | 0.75 (0.43–1.13) | 155 | 426/37270 | 89.7 | .0000 |
| Aspiration | 0.00 (0.00; 3.34) | 1 | 0/51 | .5201 | 0.00 (0.00–0.00) | 86 | 5/23449 | 0.00 | .0000 |
| Technical failure | – | – | .0707 | 0.94 (0.65–1.28) | 146 | 396/37297 | 83.4 | .0000 | |
| Procedural adverse events | 4.72 (1.35–9.73) | 1 | 5/106 | < .0001 | 0.67 (0.32–1.10) | 108 | 198/18317 | 84.1 | .0000 |
AER, adverse event rate; CI, confidence interval; IE, incomplete examination. P value between groups < .05 indicated a significant difference of adverse event rate between various VCE types. Egger test P value < .05 showed an obvious publication bias