TABLE 4.
Radiation dosimetry estimates per unit administered activity for 18F-RGD-K5 for the human adult male phantom in 1 hr and 4.8 hr bladder voiding models, based on primate biodistribution data. (n=3, mean ± SD)
| 1.0 hr model | 4.8 hr model | |
|---|---|---|
| Target Organs | μGy/MBq | μGy/MBq |
| Urinary Bladder Wall | 110±65 | 400±100 |
| Upper Large Intestine Wall | 74±8.3 | 77±8.5 |
| Small Intestine | 66±6.8 | 69±6.9 |
| Testes | 44±2.3 | 49±2.0 |
| Kidneys | 38±6.2 | 39±6.2 |
| Uterus | 19±0.3 | 37±4.6 |
| Lower Large Intestine Wall | 29±2.0 | 38±2.3 |
| Ovaries | 18±1.2 | 26±1.2 |
| Liver | 14±2.5 | 15±2.4 |
| Gallbladder Wall | 13±1.8 | 14±1.7 |
| Spleen | 11±4.2 | 11 ±4.0 |
| Heart Wall | 11±2.6 | 11±2.5 |
| Osteogenic Cells | 8.2±1.7 | 9.0±1.4 |
| Stomach Wall | 8.6±1.4 | 9.0±1.4 |
| Pancreas | 8.6±1.6 | 8.9±1.6 |
| Muscle | 6.7±1.0 | 8.8±0.4 |
| Red Marrow | 7.1±1.0 | 8.5±0.7 |
| Adrenals | 7.9±1.5 | 8.1±1.5 |
| Lungs | 5.3±1.2 | 5.3±1.2 |
| Thymus | 5.3±1.2 | 5.3±1.2 |
| Skin | 4.3±0.8 | 5.1±0.7 |
| Thyroid | 4.6±1.1 | 4.6±1.2 |
| Breast | 4.2±1.0 | 4.2±1.0 |
| Brain | 1.9±0.6 | 1.9±0.6 |
| Total Body | 7.8±1.1 | 9.7±0.6 |
| Effective dose (μSv/MBq) | 23±0.3 | 40±4.4 |