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. 2020 Nov 2;17:39. doi: 10.1186/s12014-020-09301-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — RIC versus non-RIC kidney tissue proteome profiles. Hierarchical clustering of kidney tissue proteome profiles using Euclidian distance (a). Volcano plot showing differential protein expression between RIC and non-RIC at baseline (TD0) (b) and between RIC and non-RIC 6 days post-transplant (TD6) (c). X-axis: protein level difference indicated by log2 fold change, Y-axis: statistical significance indicated by -log10 (p-value). Overall, 30 and 62 proteins, for A and B respectively, have a fold change greater than 2 (at a p-value < 0.05). Up-regulated proteins are highlighted in red, while their down-regulated counterparts are coloured blue. d Biological pathways reflected by elevated proteins in kidney tissues at day 6 (TD6), RIC versus non-RIC (Table S2). Halos in red / blue indicate the abundance levels of proteins used in this analysis. e Enriched biological process (GO-terms) from proteins shown in d