Table 5.
Underlying and Direct Causes of Death in the Comparison (No AD) and AD Cohorts of the MEDALZ-2005 Study after Excluding Deaths with Dementia as the Underlying, Direct or Intermediate Cause of Death
| Category | ICD-10 code | No AD, n = 9129 | AD, n = 10,063 | OR (95%CI) |
|---|---|---|---|---|
| Diseases of the circulatory system | I* | 5438 (59.6) | 6481 (64.4) | 1.23 (1.16, 1.30) |
| Diseases of the nervous system | G* | 124 (1.4) | 234 (2.3) | 1.73 (1.39, 2.16) |
| Neoplasms | C*, D00-D48 | 1942 (21.3) | 1573 (15.6) | 0.69 (0.64, 0.74) |
| Mental and behavioral disorders | F* | 18 (0.2) | 5 (< 0.1) | 0.25 (0.09, 0.68) |
| Diseases of the respiratory system | J* | 512 (5.6) | 380 (3.8) | 0.66 (0.58, 0.74) |
| External causes of morbidity and mortality | V*, W*, X*, Y* | 356 (3.9) | 518 (5.1) | 1.34 (1.17, 1.54) |
| Diseases of the digestive system | K* | 308 (3.4) | 423 (4.2) | 1.26 (1.08, 1.46) |
| Certain infectious and parasitic diseases | A*, B* | 89 (1.0) | 96 (1.0) | 0.98 (0.73, 1.31) |
| Diseases of the genitourinary system | N* | 132 (1.4) | 156 (1.6) | 1.07 (0.85, 1.36) |
| Endocrine, nutritional and metabolic diseases | E* | 115 (1.3) | 116 (1.2) | 0.91 (0.71, 1.19) |
| Diseases of the musculoskeletal system and connective tissue | M* | 49 (0.5) | 21 (0.2) | 0.39 (0.23, 0.64) |
| Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | D50-D89 | 10 (0.1) | 11 (0.1) | 1.00 (0.42, 2.35) |
| Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | R* | 10 (0.1) | 17 (0.2) | 1.54 (0.71, 3.37) |
| Congenital malformations, deformations and chromosomal abnormalities | Q* | 8 (0.1) | 13 (0.1) | 1.48 (0.61, 3.56) |
| Diseases of the skin and subcutaneous tissue | L* | 9 (0.1) | 4 (< 0.1) | 0.40 (0.12, 1.31) |
| Diseases of the eye, adnexa, ear and mastoid process | H* | < 2 (0.1) | 0 (0.0) | N.A |