Fig. 3.

MiR-337-3p is directly targeted by hsa_circ_0006916. a Location of hsa_circ_0006916 in hepatocellular carcinoma cells. b Potential targets of hsa_circ_0006916. c, d RNA pull-down assay demonstrated that miR-337-3p was highly expressed in hsa_circ_0006916 probe-biotin. e Binding sites between hsa_circ_0006916 and miR-337-3p. f miR-337-3p in hepatocellular carcinoma and adjacent normal samples. g Reduced miR-337-3p levels related to poor prognosis. h miR-337-3p mimics decreased the luciferase activity of hsa_circ_0006916-WT group. i hsa_circ_0006916 inhibition upregulated miR-337-3p in hepatocellular carcinoma cells. j Hsa_circ_0006916 and miR-337-3p levels have a negative correlation in hepatocellular carcinoma. *p < 0.05