Table 5.
Review of Prior Studies on the Familial Predisposition to ACL Injurya
| First Author | Study Population | Age of Patients With ACL | Relationships Assessed | FH in Patients With ACL Injury | FH in Patients Without ACL Injury | P |
|---|---|---|---|---|---|---|
| Goshima13 | ACLRs | 21b | First-degree relatives | 38/233 (16.3%) | — | — |
| Flynn11 | ACL tear vs no major knee injury | 23b | First-degree relatives | 40/171 (23.4%) | 20/171 (11.7%) | .004 |
| Hägglund14 | ACL injury vs no ACL injury | 15.0 ± 0.9 | First-degree relatives | 8/21 (38.1%) | 648/4280 (15.1%) | .004 |
| Harner15 | Bilateral ACL tears vs no knee injury history | 29.3 ± 6.8 | Immediate relatives | 11/31 (35.5%) | 1/23 (4.3%) | .008 |
| Westin30 | ACL tears vs without ACL tears | 20.5 ± 2.6 | Parents | 19/65 (29.2%) | 64/353 (18.1%) | .039 |
| Myer22 | ACLR vs meniscectomy only | 27.3 ± 0.7 | First-degree relatives | 24/120 (20.0%) | 16/107 (15.0%) | .319 |
aACL, anterior cruciate ligament; ACLR, anterior cruciate ligament reconstruction; FH, family history; —, no data available.
bSD and range not reported.