Table 3.

Management of selected AEs.

	Before starting treatment	Management
HFSR	• Examination of the hands and feet • Manicure/pedicure to remove hyperkeratotic skin • Advise patients to avoid friction or stress on skin	• Supportive measures as indicated • Regorafenib interruption and dose adjustment, in line with prescribing information (see Figure 1 for full details)
Hypertension	• Pre-existing hypertension should be controlled before the start of treatment	• Monitor blood pressure at least weekly • Patients should be advised to measure and record their blood pressure at home and to report elevation above a specified level • Hypertension should be controlled with appropriate antihypertensive therapy such as ACE inhibitors with sequential addition of a beta-blocker and calcium antagonist if needed. Diuretics should be avoided • Regorafenib interruption and dose adjustment in line with prescribing information
Fatigue		• Gentle exercise may be helpful • Thyroid replacement if hypothyroidism occurs • Prophylactic oral dexamethasone has been reported to lessen fatigue • Regorafenib interruption and dose adjustment, in line with prescribing information, may be needed for persistent fatigue

Adapted from published sources.^37,42–44

ACE, angiotensin-converting enzyme; AE, adverse event; HFSR, hand–foot skin reaction.