Table 1.
Study Characteristicsa
| Author (Year) | Pathology/Treatment | Total No. of Cases (No. of Cases per Group) | Mean Age, y (Range) | Number of PRP Injections (Interval Between Injections) | Control Group(s): (Type and No. of Injections; Interval Between Injections) | Follow-up | Coleman Methodology Score |
|---|---|---|---|---|---|---|---|
| PRP for OA treatment | |||||||
| Battaglia (2013)3 | OA K-L grades 2-4/US-guided injections | 100 (PRP group: NR; HA group: NR) | 53 (25-76) | 3 intra-articular injections (2 wk apart) | HA (3 intra-articular injections; 2 wk apart) | 1, 3, 6, and 12 mo | 89 |
| Dallari (2016)13 | OA K-L grades 1-4/US-guided injections | 111 (PRP group: 44; PRP + HA group: 31; HA group: 36) | NR (18-65) | 3 intra-articular injections (1 wk apart) | a. PRP + HA b. HA (3 intra-articular injections; 1 wk apart) |
2, 6, and 12 mo | 93 |
| Di Sante (2016)14 | OA K-L grades 2-3/US-guided injections | 43 (PRP group: 21; HA group: 22) | 72.5 (NR) | 3 intra-articular injections (1 wk apart) | HA (3 intra-articular injections; 1 wk apart) | 1 and 4 mo | 84 |
| Doria (2017)15 | OA K-L grades 0-2/US-guided injections | 80 (PRP group: 40; HA group: 40) | 67.6 (40-72) | 3 intra-articular injections (1 wk apart) | HA (3 intra-articular injections; 1 wk apart) | 6 and 12 mo | 83 |
| PRP augmentation for FAIS and labral surgery | |||||||
| Redmond (2015)42 | FAIS + labral tear/arthroscopic labral repair or debridement with or without acetabuloplasty, femoroplasty, microfracture, and/or capsular repair | 271 (PRP group: 91; bupivacaine group: 180) | 36.2 (NR) | Single intra-articular injection at the end of surgery | 0.25% bupivacaine (single intra-articular injection at the end of surgery) | 3 and 24 mo | 86 |
| LaFrance (2015)29 | FAIS + labral tear/arthroscopic labral repair + femoral osteochondroplasty | 35 (PRP group: 20; normal saline group: 15) | 34.6 (18-63) | Single intra-articular injection at the end of surgery | 0.9% normal saline (single intra-articular injection at the end of surgery) | 1, 3, 6, and 12 mo | 83 |
| Rafols (2015)41 | FAIS + labral tear/arthroscopic labral repair + femoral osteochondroplasty | 57 (PRP group: 30; no injection group: 27) | 35.3 (16-52) | Single intra-articular injection at the end of surgery | No injection | 2 d; 3, 6, and 24 mo | 93 |
aFAIS, femoroacetabular impingement syndrome; HA, hyaluronic acid; K-L, Kellgren-Lawrence classification; NR: not reported; OA, osteoarthritis; PRP, platelet-rich plasma; US, ultrasound.