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. 2020 Nov 2;21:755. doi: 10.1186/s12864-020-07131-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Grouping of mutants in clusters. a. Number of genes per cluster. The number of mutants in each cluster is shown. Data are taken from Additional file 1. The clustering algorithm was a weighted PAM. See Methods for details. The numbers above the bars indicate the number of genes per cluster. b. Number of clusters in different size ranges. Clusters were sorted into bins according to the number of genes in the cluster. The number of clusters corresponding to each size range (bin) is shown. The numbers above the bars indicates the number of clusters in each size range. Raw data are available in Additional file 1