Fig. 3.

a-h: Relative mRNA transcript expression (delta CT values) of different pro-inflammatory cytokine genes TNF-α (A/B), IL-6 (C/D), IL-1α (E/F) and IL-1β (G/H) in IL10RA KO MAC-T cells (KO) and unedited (WT) MAC-T cells following 24 and 48 h stimulation with MAP lysate, MAP lysate + IL10, or LPS (5 μg/ml). Values (mean ± SEM, n = 4 representing independent replicate experiments) with asterisks indicate a significant difference: *** denotes significant differences at P < 0.001;** denotes significant differences at P < 0.01