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. Author manuscript; available in PMC: 2020 Nov 3.
Published in final edited form as: J Med Chem. 2018 May 10;61(10):4370–4385. doi: 10.1021/acs.jmedchem.7b01820

Figure 7.

Figure 7.

Mouse hypothermia study of 25 and 2. Female C57BL6 mice (10 weeks) were dosed with a test agent (2, 25, or the vehicle) by oral gavage as indicated in the Experimental Section. Thirty minutes after being dosed with the inhibitor, the animals were administered CP55940 by ip injections. Rectal-temperature data were collected at regular intervals. Compound 2 blocked hypothermia induced by CP55940 (two-way ANOVA, p < 0.05) compared with the animals treated with the vehicle only, but this effect was absent in the animals dosed with 25.