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tRNAVal(AAC) purified from LCLs of patients with the PUS7.Asp503Tyr mutation have reduced Ψ relative to that from control LCLs. LCLs were grown and tRNA was purified and analyzed for modifications as described in Materials and Methods. Data derives from Table 1, showing that Ψ levels are reduced in patient LCLs (by 0.88 mole/mole), whereas levels of each of two other modifications are not.
