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. 2020 Nov 3;183(6):1508–1519.e12. doi: 10.1016/j.cell.2020.10.052

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© 2020 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Temporal Evolution of SARS-CoV-2-Specific Antibody Features

(A–C) Uniform Manifold Approximation and Projection (UMAP) was used to visualize the multivariate data in two dimensions. Each point represents a given individual at a single time point and colors indicate age (A), sex (B), and group (C).

(D) Normalized antibody levels are shown over time, plotted by days after symptom onset, for the severe and deceased group. Each dot is an individual measurement, the lines show smoothed non-parametric regression models (loess), and the color indicates the antigen specificity. See also Figure S2 and Data S1.