REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
APC-Cy7 Mouse Anti-Human CD16	BD Biosciences	CAT#557758; RRID:AB_396853
CD56 PE-Cy7 Mouse Anti-Human CD56	BD Biosciences	CAT#557747; RRID:AB_396853
PE MIP-1b Mouse anti-Human	BD Biosciences	CAT#550078; RRID:AB_393549
Pacific Blue™ Mouse Anti-Human CD3	BD Biosciences	CAT#558117; RRID:AB_1595437
FITC Goat IgG anti-C3	MP Biomedicals	CAT#: 855385
Mouse Anti-Human IgG1-Fc PE	Southern Biotech	CAT # 9054-09; RRID:AB_2796628
Mouse Anti-Human IgG2-Fc PE	Southern Biotech	CAT # 9060-09; RRID:AB_2796635
Mouse Anti-Human IgG3-Hinge PE	Southern Biotech	CAT # 9210-09; RRID:AB_2796701
Mouse Anti-Human IgG4-Fc PE	Southern Biotech	CAT # 9200-09; RRID:AB_2796693
Mouse Anti-Human IgA1-Fc PE	Southern Biotech	CAT # 9130-09; RRID:AB_2796656
Mouse Anti-Human IgM-Fc PE	Southern Biotech	CAT # 9020-09; RRID:AB_2796577
BV605 Mouse Anti-Human CD11b	BD Biosciences	CAT# 562721; RRID:AB_2737745
Bacterial and Virus Strains
SARS-CoV-2-S pseudovirus with a luciferase reporter	This paper	N/A
Chemicals, Peptides, and Recombinant Proteins
SARS-CoV-2 S	Obtained from the lab of Dr. Eric Fischer	N/A
SARS-CoV-2 RBD	Obtained from the lab of Dr. Aaron Schmidt	N/A
HKU1 RBD	Obtained from the lab of Dr. Aaron Schmidt	N/A
NL63 RBD	Obtained from the lab of Dr. Aaron Schmidt	N/A
SARS-CoV-2 N	Aalto Bio Reagents	CAT # CK 6404-b
Human Fc receptors	Produced at the Duke Human Vaccine Institute, {Boesch, 2014 #15}	N/A
Streptavidin-R-Phycoerythrin	Prozyme	CAT#:PJ31S
FIX&Perm Cell Permeabilization Kit	Life Tech	CAT#: GAS001S100 CAT#: GAS002S100
Brefeldin A	Sigma Aldrich	CAT #: B7651
GolgiStop	BD Biosciences	CAT #: 554724
Luciferase Assay Reagent	Promega	CAT#: E1483
SARS-CoV-2 S1 trimer	Kindly provided by Bing Chen	N/A
SARS-CoV-2 S1	Sino Biological	CAT #: 40591-V08B1
SARS-CoV-2 S2	Sino Biological	CAT #: 40590-V08B
HA A/Michigan/45/2015 (H1N1)	Immunetech	IT-003-00105DTMp
HA A/Singapore/INFIMH-16-0019/2016 (H3N2)	Immunetech	IT-003-00434DTMp
HA B/Phuket/3073/2013	Immunetech	IT-003-B11DTMp
Critical Commercial Assays
BirA-500: BirA biotin-protein ligase standard reaction kit	Avidity	CAT#: BirA500
RosetteSep Human NK Cell Enrichment Cocktail	Stem Cell Technologies	CAT#: 15065
Steady-Glo Luciferase Assay	Promega	CAT#: E2510
Deposited Data
Generated Data and Code	This paper	Mendeley Data: http://dx.doi.org/10.17632/97m5dtkg4t.1
Experimental Models: Cell Lines
THP-1 Cells	ATCC	CAT#: TIB-202 RRID: CVCL_0006
HL-60	ATCC	CAT#: CCL-240
Recombinant DNA
psPAX2	AIDS Reagent	CAT#11348
pLenti-CMV Puro-Luc	Addgene	CAT#17447
pcDNA3.1-SARS CoV-2.SDCT	This paper	N/A
pcDNA3.1(-)-hACE2	Addgene	CAT# 1786
Software and Algorithms
Intellicyt ForeCyt Software	Sartorious	https://intellicyt.com/products/software/
Python programming language	Version 3.6.8	https://www.python.org/
R programming language	Version 3.6.1	https://www.r-project.org/
Other
FluoSpheres™ NeutrAvidin™-Labeled Microspheres, 1.0 μm, yellow-green fluorescent (505/515), 1% solids	Invitrogen	CAT#: F8776
FluoSpheres™ NeutrAvidin™-Labeled Microspheres, 1.0 μm, red fluorescent (505/515), 1% solids	Invitrogen	CAT#: F8775
MagPlex microspheres	Luminex corporation	CAT#: MC12001-01, MCI12040-01, MCI10077-01