Table II.

Univariate and multivariate analyses of prognostic factors of overall survival for patients with hepatocellular carcinoma.

	Univariate analyses			Multivariate analyses
Baseline variable	HR	95% CI	P-value	HR	95% CI	P-value
Age, >47 years	0.696	0.250–1.936	0.488
Sex, male	3.010	0.694–13.045	0.141
HBsAg (+)	1.521	0.351–6.590	0.575
AFP, >20 ng/ml	2.340	0.681–8.047	0.177
Preoperative WBC, 109/l	1.030	0.830–1.297	0.786
Preoperative neutrophil, 109/l	1.087	0.855–1.334	0.427
Preoperative lymphocyte, 109/l	0.534	0.255–1.266	0.154
Albumin, g/dl	0.920	0.841–1.007	0.071
Postoperative WBC, 109/l	1.040	0.848–1.277	0.704
Postoperative neutrophil, 109/l	1.224	0.939–1.596	0.135
Postoperative lymphocyte, 109/l	0.682	0.291–1.599	0.379
Cirrhosis, yes	0.943	0.382–2.330	0.899
Tumor size, >5 cm	2.795	1.099–7.110	0.031
Tumor number, multiple	1.549	0.513–4.681	0.438
Differentiation, poor	3.079	1.001–9.473	0.050
Biliary leakage	0.048	0.000–70634.465	0.675
Pleural effusion	0.688	0.227–2.086	0.508
Pneumonia	0.941	0.126–7.060	0.953
Perihepatic effusion	0.048	0.000–103525.973	0.683
Preoperative NLR	4.618	1.728–12.339	0.002
Postoperative NLR	3.512	1.381–8.934	0.008
Preoperative NLR plus Postoperative NLR	2.985	1.648–5.407	<0.001	2.985	1.648–5.407	<0.001
Postoperative NLR change	0.548	0.182–1.654	0.286
Postoperative NLR minus Preoperative NLR	3.296	1.181–9.199	0.023

HR, hazard ratio; CI, confidence interval; AFP, alpha-fetoprotein; HBsAg, hepatitis B surface antigen; NLR, neutrophil-lymphocyte ratio; WBC, white blood cells.