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. 2020 Oct 30;218(2):e20192423. doi: 10.1084/jem.20192423

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© 2020 Dong et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — miR-155 promotes tT reg cell development in both T cell–intrinsic and –extrinsic manners. (A–C) FACS analysis (A), frequencies (B), and absolute numbers (C) of total Foxp3⁺ T reg cells in the thymus of 5–6-wk-old WT and T-cKO mice. (D) Percentages of the reduction of tT reg cell frequencies (on the basis of corresponding WT controls) in miR-155 null and T-cKO mice. Each symbol represents an individual mouse, and the bar represents the mean. Data are pooled from at least three independent experiments. Results of Student’s t test: *, P < 0.05; ***, P < 0.001.