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. 2020 Oct 30;218(2):e20192423. doi: 10.1084/jem.20192423

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© 2020 Dong et al.

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Figure 5. — Tgfbr2 heterozygosity in TECs restores mature mTEC and tT reg cell phenotypes in TEC-cKO mice. (A and B) FACS analyses (A) and frequencies (B) of Foxp3⁺ T reg cells in the thymus of 6–8-wk-old WT and TEC-cKO mice treated daily with the TGFβRI kinase inhibitor SB431542 or vehicle only via i.p. injection from day 1 to day 6 and analyzed 12 d after the first injection. (C and D) FACS analysis (C) and frequencies (D) of CD80^hiMHCII^hi mature mTECs in the thymus of 5–6-wk-old WT, TEC-cKO, and TEC-cKO/Tgfbr2^fl/+mice. (E and F) FACS analysis (E) and frequencies (F) of Foxp3⁺ T reg cells in the thymus of 5–6-wk-old WT, TEC-cKO, and TEC-cKO/Tgfbr2^fl/+mice. Each symbol represents an individual mouse, and the bar represents the mean. Data are pooled from at least three independent experiments. Results of Student’s t test: **, P < 0.01; ***, P < 0.001; ns, not significant.