Table 2.

Public Health Impact of Setting I^*

	No Interaction			Negative Interaction			Positive Interaction
	8000 PYsϮ	21300 PYs	36000 PYs	8000 PYs	21300 PYs	36000 PYs	8000 PYs	21300 PYs	36000 PYs
	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI
Single-factor Design
PrEP	0.999	1.000	1.000
TasP	0.574	0.320	0.300
LtC	0.998	0.997	0.997
Counseling	0.980	0.958	0.936
Condom	0.915	0.800	0.743
ColMean Ϯ Ϯ	0.875	0.789	0.771
Factorial Design
PrEP+LtC	0.997	0.998	0.997	0.999	0.999	0.999	0.994	0.994	0.992
PrEP+Counseling	0.983	0.964	0.942	0.992	0.991	0.989	0.963	0.917	0.874
PrEP+Condom	0.923	0.830	0.755	0.976	0.955	0.929	0.862	0.726	0.689
TasP+LtC	0.583	0.318	0.300	0.628	0.340	0.301	0.536	0.308	0.298
TasP+Counseling	0.595	0.321	0.286	0.716	0.412	0.315	0.498	0.280	0.252
TasP+Condom	0.573	0.293	0.237	0.762	0.497	0.357	0.425	0.200	0.163
ColMean	0.776	0.621	0.586	0.846	0.699	0.648	0.713	0.571	0.545
Multi-arm Design
PrEP|LtC	0.995	0.997	0.997	0.995	0.997	0.997	0.995	0.997	0.997
PrEP|Counseling	0.981	0.968	0.952	0.981	0.968	0.952	0.980	0.968	0.952
PrEP|Condom	0.929	0.848	0.788	0.930	0.849	0.788	0.929	0.848	0.788
TasP|LtC	0.684	0.375	0.310	0.685	0.376	0.311	0.684	0.374	0.309
TasP|Counseling	0.677	0.381	0.294	0.681	0.389	0.306	0.674	0.374	0.284
TasP|Condom	0.674	0.351	0.246	0.686	0.394	0.310	0.666	0.321	0.201
ColMean	0.823	0.653	0.598	0.826	0.662	0.611	0.821	0.647	0.588
All-in-one Design
All-in-one	0.537	0.123	0.088	0.846	0.541	0.328	0.286	0.060	0.059

^*Underlying HRs of PrEP, TasP, LtC, Counseling, and Condom Use are 0.56, 0.3, 0.9, 0.8, and 0.7, respectively.

^ϮPerson-years.

^ϮϮIn single-factor design, half weight is given to the biomedical rows and half weight to the three behavioral rows.