Table 3.

Public Health Impact of Setting IIb^*

	No Interaction			Negative Interaction			Positive Interaction
	8000 PYsϮ	21300 PYs	36000 PYs	8000 PYs	21300 PYs	36000 PYs	8000 PYs	21300 PYs	36000 PYs
	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI	.95 CI
Single-factor Design
PrEP	0.999	1.000	1.000
TasP	0.574	0.320	0.300
LtC	1.000	1.000	1.000
Counseling	1.000	1.000	1.000
Condom	0.915	0.800	0.743
ColMean Ϯ Ϯ	0.879	0.797	0.782
Factorial Design
PrEP+LtC	0.998	1.000	1.000	0.998	1.000	1.000	0.998	1.000	1.000
PrEP+Counseling	0.999	1.000	1.000	0.999	1.000	1.000	0.999	1.000	1.000
PrEP+Condom	0.923	0.830	0.755	0.976	0.955	0.929	0.862	0.726	0.689
TasP+LtC	0.560	0.312	0.301	0.560	0.312	0.301	0.560	0.312	0.301
TasP+Counseling	0.584	0.326	0.301	0.584	0.326	0.301	0.584	0.326	0.301
TasP+Condom	0.573	0.293	0.237	0.762	0.497	0.357	0.425	0.200	0.163
ColMean	0.773	0.627	0.599	0.813	0.682	0.648	0.738	0.594	0.576
Multi-arm Design
PrEP|LtC	0.997	1.000	1.000	0.997	1.000	1.000	0.997	1.000	1.000
PrEP|Counseling	0.997	0.998	1.000	0.997	0.998	1.000	0.997	0.998	1.000
PrEP|Condom	0.929	0.848	0.788	0.930	0.849	0.788	0.929	0.848	0.788
TasP|LtC	0.683	0.376	0.310	0.683	0.376	0.310	0.683	0.376	0.310
TasP|Counseling	0.683	0.390	0.307	0.683	0.390	0.307	0.683	0.390	0.307
TasP|Condom	0.674	0.351	0.246	0.686	0.394	0.310	0.666	0.321	0.201
ColMean	0.827	0.660	0.608	0.829	0.668	0.619	0.826	0.656	0.601
All-in-one Design
All-in-one	0.813	0.475	0.243	0.977	0.956	0.940	0.548	0.111	0.082

^*Underlying HRs of PrEP, TasP, LtC, Counseling, and Condom Use are 0.56, 0.3, 1.0, 1.0, and 0.7, respectively.

^ϮPerson-years.

^ϮϮIn single-factor design, half weight is given to the biomedical rows and half weight to the three behavioral rows.