Fig. 3.

S100a10^−/− mice have more proinflammatory cytokine production when challenged with LPS and are more susceptible to endotoxic shock. a WT and S100a10^−/− mice (n = 5 per group) were injected intraperitoneally with LPS (5 mg/kg). The concentrations of TNF-α, IL-6, and IFN-β in sera were measured by ELISA 6 h after LPS injection. b WT and S100a10^−/− mice (n = 5 per group) were injected intraperitoneally with LPS (10 mg/kg). Survival was monitored until 96 h after the initiation of injection. c Hematoxylin and eosin staining of lungs from WT and S100a10^-−/− mice 6 h after challenge with LPS. Original magnification, ×100. Data are representative of three experiments (mean ± SEM of five samples; *P < 0.05; ***P < 0.001)