Table 4.
Univariate and multivariable logistic regression analysis for treatment with enucleation.
| Risk factors for enucleation | Univariate logistic regression analysis | Multivariable logistic regression analysis | ||||
|---|---|---|---|---|---|---|
| Crude OR | 95% CI | p value | Adjusted OR | 95% CI | p value | |
| Age | 1.007 | 0.998–1.016 | 0.113 | – | – | – |
| Family history | 0.292 | 0.136–0.629 | 0.002 | – | – | – |
| Tumour class by ICRB (A) | <0.001 | – | – | – | ||
| B | 3.485 | 0.439–27.681 | 0.238 | – | – | – |
| C | 4.583 | 0.496–42.353 | 0.180 | – | – | – |
| D | 23.956 | 3.101–185.057 | 0.002 | – | – | – |
| E | 112.750 | 14.165–897.437 | <0.001 | – | – | – |
| Presence of vitreous seeds | 9.510 | 5.917–15.283 | <0.001 | 4.246 | 2.260–7.976 | <0.001 |
| Presence of subretinal seeds | 4.709 | 3.064–7.235 | <0.001 | – | – | – |
| Absence of EBRT | 0.504 | 0.284–0.893 | 0.019 | 0.411 | 0.182–0.931 | 0.033 |
| Number of cryotherapy applications (=0) | <0.001 | – | – | – | ||
| 1–4 | 0.170 | 0.096–0.299 | <0.001 | – | – | – |
| 5–9 | 0.587 | 0.239–1.440 | 0.245 | – | – | – |
| 10–15 | 0.782 | 0.155–3.948 | 0.766 | – | – | – |
| Number of TTT applications (=0) | <0.001 | – | – | 0.028 | ||
| 1–4 | 0.276 | 0.169–0.450 | <0.001 | 0.719 | 0.363–1.424 | 0.344 |
| 5–9 | 0.600 | 0.265–1.357 | 0.220 | 3.121 | 1.113–8.751 | 0.031 |
| Tumour base diameter (mm) (Each 1 mm increase) | 1.202 | 1.142–1.264 | <0.001 | 1.175 | 1.112–1.242 | <0.001 |
OR odds ratio, CI confidence interval, ICRB international classification of retinoblastoma, EBRT external beam radiotherapy, TTT transpupillary thermotherapy.