Table 3.
Effects of the selective inhibitors on the formation of metabolites during HLMs incubations
| Name | MS area | Relative MS area (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HLM | ANF | QUE | SPZ | TCL | QD | KET | CMT | ABT | |
| Control | 1A2 | 2C8 | 2C9 | 2B6/2C19 | 2D6 | 3A | 2E1 | CYPS | |
| M0 | 2.47 × 105 | 89 | 92 | 58 | 61 | 94 | 227 | 87 | 165 |
| M224 | 2.32 × 103 | 127 | 70 | 88 | 94 | 80 | 36 | 100 | 26 |
| M484 | 2.42 × 103 | 101 | 62 | 89 | 84 | 39 | — | 136 | — |
| M486 | 5.77 × 103 | 147 | 31 | 92 | 86 | 113 | 18 | 131 | 19 |
| M497 | 1.49 × 103 | 81 | 37 | 62 | 62 | 40 | — | 89 | — |
| M539 | 1.82 × 103 | 67 | 57 | 62 | 55 | 58 | — | 81 | — |
| M554-1 | 2.12 × 103 | 96 | 53 | 58 | 58 | 100 | 109 | 83 | 76 |
| AST5902 | 7.84 × 104 | 97 | 32 | 55 | 62 | 54 | 14 | 88 | 2 |
| M555 | 2.24 × 103 | 74 | 51 | 65 | 44 | 64 | 0 | 73 | — |
| M584-1 | 1.04 × 103 | 112 | 38 | 65 | 143 | 121 | 59 | 115 | — |
| M584-2 | 1.83 × 103 | 126 | 76 | 85 | 77 | 161 | — | 96 | 31 |
| M584-3 | 1.74 × 103 | 80 | 82 | 99 | 75 | 66 | 32 | 122 | 32 |
| M586 | 9.00 × 102 | 117 | 64 | 91 | 111 | 88 | — | 111 | — |
| M600 | 2.60 × 103 | 95 | 85 | 85 | 104 | 93 | 13 | 102 | 12 |