Table 1.

Key biochemical indicators in CNS diseases after FAAH and MAGL inhibitors therapy in the animal

Type of the inhibitors	Name	Biochemical indicators	References
FAAH inhibitors	N-arachidonoyl serotonin	CORT ↓	[76]
	URB597	CORT↓	[75, 81]
		COX-2, PGE2, NO ↓	[91]
		DOPA ↑	[104]
	URB694	CORT ↓	[79]
	ST4070	CORT ↓	[80]
	SSR411298	CORT ↓	[82]
	PF-3845	BDNF ↑	[106]
MAGL inhibitors	JZL184	CORT ↓	[86]
		IL-1β, TNF-α ↓	[90]
		Aβ ↓	[102, 103]
	KML29	DOPA, GDNF ↑	[106]

PGE2 prostaglandin E2, NO nitric oxide, DOPA dopamine, BDNF brain-derived neurotrophic factor, GDNF glial cell line-derived neurotrophic factor, IL-1β interleukin-1β, TNF-α tumor necrosis factor-α, CORT corticosterone, COX-2 cyclooxygenase-2