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. 2020 Jul 3;30(10):873–884. doi: 10.1038/s41422-020-0363-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Overview of the MCP interaction network. Two penton MCPs (Pen1 and Pen2) are displayed. b, c Three types of MCP-MCP interactions among hexons. d Interactions between penton MCPs and hexon MCPs. e Enlarged view of the boxed region in d, showing the N-terminus of the penton MCP inserting into a hydrophobic groove (inset). The hydrophobic residues are highlighted by side chain showing (inset). f Comparison of buttress domains of hexon and penton MCPs. The MCP tower and floor regions are labeled, respectively. g The MCP-SCP interactions in pentons and hexons. h Overview of triplexes and MCPs. i, j Superimposition of triplexes Ta-Te by aligning their main bodies, showing the Tri1 N-anchor of Ta rotated ~120° counterclockwise.