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. 2020 Apr 30;30(9):732–744. doi: 10.1038/s41422-020-0328-3

Fig. 7. ERCC6L2 activity is required for directional end-joining during CSR.

Fig. 7

a CSR levels to IgG1 in CSR-activated WT and Ercc6l2D270N B cells at Day 4 upon LPS/IL4 stimulation. b Distribution of Sμ–Sγ1 junctions at Sγ1, end-resection and inversion/deletion ratio of CSR junctions in WT and Ercc6l2D270N B cells. Dashed lines indicate the levels in 53bp1−/− B cells, which were assayed at the same time. c A working model to explain roles of ERCC6L2, see “Discussion” for details. Data are represented as mean ± SD and two-tail unpaired t-test was performed in (a, b). ***p < 0.001, *p < 0.05.