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. 2017 Oct 5;36(40):5658–5660. doi: 10.1038/onc.2017.239

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© Macmillan Publishers Limited, part of Springer Nature. 2017

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Low expression of GABARAP and VAMP2 is prognostic for worse survival in KRAS-G12-positive PAAD. Survival curves of PAAD patients with low (black) or high (red) expression of GABARAP (a) and VAMP2 (b). Low expression of GABARAP (c) or VAMP2 (d) correlates with worse clinical outcome in patients (a and b) and with enrichment for G12-activating mutations in KRAS (e and f), suggesting that these autophagy-related genes behave as tumour suppressors in PAAD with KRAS-activating mutations. Statistics: Fisher’s exact t-test.