Table 1.
Performance metrics used in the evaluation of polygenic hazard scores.
Performance metric | Description |
---|---|
HR98/50 | Hazard ratio of the top 2% to the average (30–70%) in the test set |
HR20/50 | Hazard ratio of the bottom 20% to the average (30–70%) in the test set |
HR98/20 | Hazard ratio of the top 2% to the bottom 20% in the test set |
HR80/20 | Hazard ratio of the top 20% to the bottom 20% in the test set |
z-score | z-score of Cox proportional hazards model using PHS as a sole predictor of age in the test set |
beta | Coefficient of PHS in a Cox proportional hazards model using PHS as a sole predictor of age in the test set |