Table 2.

NCI-CTCAE version 4.03 grading of HFSR.

Grade	Description
I	Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain
II	Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL
III	Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self-care ADL

ADL activities of daily living, HFSR hand–foot skin reaction, NCI-CTCAE National Cancer institute Common Terminology Criteria for Adverse Events.