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. 2020 May 26;30(10):914–927. doi: 10.1038/s41422-020-0341-6

Fig. 4. Usp29m/m mice are hypersensitive to HSV-1 infection.

Fig. 4

a Survival (Kaplan–Meier curve) of Usp29+/+ (n = 11) and Usp29m/m mice (n = 13) intravenously injected with HSV-1 (1.5 × 106 PFU per mouse) monitored survival for 12 days. b ELISA analysis of IFN-β, IFN-α, and CCL5 in the sera of Usp29+/+ and Usp29m/m mice (n = 5) intravenously injected with HSV-1 (2 × 106 PFU per mouse) for 12 h. c qRT-PCR analysis of Ifnb, Ifna4, Ip10, Il6, Tnf or HSV-1 UL30 mRNA in the lung from Usp29+/+ and Usp29m/m mice intravenously injected with HSV-1 (2 × 106) for 24 h. d, e qRT-PCR analysis of Ifnb, Ccl5, Il6 and HSV-1 UL30 (d) and plaque assays (e) of the brains from Usp29+/+ and Usp29m/m mice intraperitoneally injected with HSV-1 (2 × 106) for 4 days. *P < 0.05; **P < 0.01; ***P < 0.001 (two-tailed Student’s t-test, b–e). Data are of combined two independent experiments (a) or representative of two (b–e) independent experiments (means ± SD in b–e).