Table 2.
[‘Responders vs controls, objective assessments section’ (changes underscored)]
| Chr | Index SNP | A1/A2 | Freq | OR | P-value | N | Position | KB | Genes |
|---|---|---|---|---|---|---|---|---|---|
| 11 | rs146727601 | −T/A | 0.01 | 4.12 | 1.22 × 10 −9 | 2 | 112118590–112343856 | 225 | PTS,PLET1 |
| 2 | rs116323614 | A/G | 0.03 | 2.69 | 1.53 × 10 −6 | 58 | 179859406–180139219 | 280 | SESTD1,CCDC141 |
| 19 | rs77866734 | C/T | 0.98 | 0.29 | 7.59 × 10 −7 | 11 | 1633923–1642221 | 8 | TCF3, KIR3DP1, KIR2DL4 |
| 17 | rs142643109 | T/G | 0.98 | 0.31 | 4.04 × 10 −6 | 3 | 60086587–60497572 | 411 | TBC1D3P2, MIR4315-2, MIR4315-1, METTL2A, MED13, EFCAB3 |
Abbreviations: A1/A2, alternate and reference allele; Chr, chromosome; Freq, frequency of alternate allele; Index SNP, the single-nucleotide polymorphism with the strongest association in the genomic region; LD, linkage disequilibrium; MHC, major histocompatibility complex; N, number of SNPs in the reported region; OR, odds ratio.
We used LD clumping to define regions of association. Positions are given in UCSC hg19 coordinates. Lines in bold indicate associations that were genome-wide statistically significant.