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. 2020 Oct 30;12:10887–10896. doi: 10.2147/CMAR.S277432

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© 2020 Wang et al.

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MiR-206 overexpression suppressed AML cell progression through targeting PRKACB. MiR-NC, miR-206, miR-206+vector or miR-206+PRKACB was transfected into THP-1 and HL-60 cells. (A) PRKACB protein level in THP-1 and HL-60 cells was measured by Western blot assay. (B–E) The proliferation, colony formation and apoptosis of THP-1 and HL-60 cells were assessed through CCK-8 assay, colony formation assay and flow cytometry analysis, respectively. (F and G) The protein levels of Bax, Bcl-2 and c-caspase-3 in THP-1 and HL-60 cells were measured by Western blot assay. (H and I) The cell cycle process was analyzed by flow cytometry analysis. (J and K) The migration and invasion of THP-1 and HL-60 cells were evaluated by transwell assay. *P<0.05.