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. Author manuscript; available in PMC: 2020 Nov 3.
Published in final edited form as: Curr Opin Immunol. 2019 Jun 8;58:98–103. doi: 10.1016/j.coi.2019.04.014

Figure 1. Heterogeneity of exhausted CD8 T cells during chronic viral infections.

Figure 1

Virus-specific exhausted CD8 T cells consist of an exhausted TCF1+ PD1int T cell population with memory/stem cell-like characteristics which gives rise to a terminally differentiated, exhausted TCF1low/neg PD1hiT cell population. PD1/PDL checkpoint blockade reinvigorates the TCF1+ PD1int progenitor population but not the terminally differentiated TCF1 low/neg T cell population.