Table 1.

Ocular Non-Neuro-Ophthalmological Manifestations of Patients Infected with HCoVs

Study	Virus	Study Type	Sample Size	Ocular Non Neuro-Ophthalmological Manifestations
Van Der Hoek L et al 200423	HCoV NL63	Case report	One	Conjunctivitis
Wu P. et al. 201915	SARS-CoV-2	Case series	38 total 12 with ocular manifestations	Conjunctivitis characterized by chemosis, epiphora, conjunctival hyperemia and secretion; Two Positive conjunctival swab
Xia et al 202019		Prospective interventional case series	30 total One with ocular manifestations	Conjunctival hyperemia, aqueous secretion; Positive conjunctival swab
Navel V. et al 202018		Case report	One	Conjunctival hyperemia, secretion, follicles, petechiae, tarsal hemorrhages, chemosis, punctuate keratitis superficial punctuate keratitis, pseudomembranous tarsal reaction
Zhou Y. et al 202016		Cross sectional	121 total Eight with ocular symptoms	Itching, redness, tearing, discharge, foreign body sensation; Positive conjunctival swab (1)
Hong N. et al 202017		Cross sectional	56 total 15 with ocular symptoms	Eye pain, itching, foreign body sensation, tearing, redness, dry eyes, eye secretions, floaters
Chen L. et al 202020		Case report	One	Follicular conjunctivitis, palpable preauricular lymph node
Cheema M et al 202021		Case report	One	Keratoconjunctivitis, conjunctival follicular reaction and corneal subepithelial infiltrates
Marinho P. et al 202028		Cross sectional	12	Cotton wool spots, retinal hemorrhages, bilateral hyper-reflective lesions in ganglion cell and inner plexiform layers
Daruich A. et al 202024		Case report	One	Foreign body sensation, eyelid edema, conjunctival hyperemia; Intense headache*
Sirakaya E. et al 202026		Case report	One	Bilateral acute follicular conjunctivitis; Positive conjunctival swab

Notes: *We considered these symptoms/signs as part of neuro-ophthalmological manifestations. The numbers in parentheses represent the number or percentage of patients who presented with the symptom and/or sign.

Abbreviations: HCoVs, human coronavirus; SARS-CoV-2, severe acute respiratory syndrome-related coronavirus-2;