Table 1.
Significantly differentially abundant pathways between HC and IBS females.
| Pathways | Total | Expected | Hits | p value | −Log(p) | q valuea | Impact |
|---|---|---|---|---|---|---|---|
| Aminoacyl-tRNA biosynthesis | 75 | 2.6485 | 11 | 4.28E−05 | 10.058 | 0.002184 | 0.11268 |
| Pyrimidine metabolism | 60 | 2.1188 | 9 | 0.0001886 | 8.5759 | 0.004810 | 0.22819 |
| Alanine, aspartate, and glutamate metabolism | 24 | 0.84753 | 5 | 0.001221 | 6.7081 | 0.020757 | 0.23362 |
| Beta-alanine metabolism | 28 | 0.98878 | 5 | 0.002526 | 5.9812 | 0.032203 | 0.07744 |
| Glutathione metabolism | 38 | 1.3419 | 5 | 0.009777 | 4.6278 | 0.092727 | 0.04893 |
| Nitrogen metabolism | 39 | 1.3772 | 5 | 0.010909 | 4.5182 | 0.092727 | 0.00000 |
| Valine, leucine, and isoleucine biosynthesis | 27 | 0.95347 | 4 | 0.013666 | 4.2928 | 0.099567 | 0.11553 |
| Histidine metabolism | 44 | 1.5538 | 5 | 0.017928 | 4.0214 | 0.111191 | 0.14053 |
| Phenylalanine metabolism | 45 | 1.5891 | 5 | 0.019622 | 3.9311 | 0.111191 | 0.05939 |
| Glycine, serine, and threonine metabolism | 48 | 1.6951 | 5 | 0.025326 | 3.6759 | 0.129163 | 0.32425 |
| Ubiquinone and other terpenoid-quinone biosynthesis | 36 | 1.2713 | 4 | 0.036090 | 3.3217 | 0.167326 | 0.06488 |
| Purine metabolism | 92 | 3.2489 | 7 | 0.041258 | 3.1879 | 0.175347 | 0.06907 |
ap value was calculated with FDR correction.