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. 2020 Nov 2;10:18857. doi: 10.1038/s41598-020-75258-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced mRNA and protein expression of PINK1 and PARK2 are associated with shorter overall survival. The mRNA expression levels of PINK1 were dichotomized by the best cutoff (A) and the median (B); A lower PINK1 expression was highly significantly associated with an adverse prognosis. The same adverse effect was observed for lower mRNA expression levels of PARK2 after dichotomization (C, D). Also when comparing the first quartile to the fourth quartile and combining the second and third quartiles as an intermediate group, the mRNA expression levels of PINK1 (E) and PARK2 (F) are significantly associated with prognosis. The protein expression was dichotomized in high (moderate or strong expression) and low (negative or weak expression). Patients with low protein expression of PINK1 had a significantly lower overall survival (in months) compared to patients with high protein staining (G). No significant association with survival was noticed for PARK2, protein expression (H); Kaplan Meier plots, including a log-rank test with p ≤ 0.05 being significant.