Figure 1.

Simplified schematic of GpHR complex signaling. FSHR and LHR G protein-dependent and independent pathway activation through receptor–receptor interactions, receptor–G signaling protein interactions, and receptor–adapter/scaffolding protein interactions. Dashed lines represent currently hypothesized/unresolved mechanisms of pathway activation and/or cross talk, blunt ended arrows, inhibitory pathways and spear-headed arrows, activated pathways. The FSHR and LHR are represented as single receptors for simplicity, but from our current knowledge they reside as both homomers and monomers.