Overall survival (OS) by indication. Median survival is represented by the dashed lines and reported in the legend. Solid red circles represent estimates of survival probabilities from the corresponding pivotal clinical trials extracted using the Engauge Digitizer software. 1L, first line; 2L+, second or subsequent line; HCC, hepatocellular carcinoma; ICI, immune checkpoint inhibitor; ipi, ipilimumab; nivo, nivolumab; NSCLC, non–small-cell lung cancer; pembro, pembrolizumab; RCC, renal cell carcinoma; SCCHN, squamous cell carcinoma of the head and neck; VA, Veterans Affairs.