Table 1.
Patient characteristics.
| Population A | Population B | ||
|---|---|---|---|
| Sequenced HIV-1 genomic region | Near full-length | Partial pol | |
| n | 351 | 610 | |
| Age at first HIV-1 DNA sample, in years (median [IQR]) | 42 [37,48] | 43 [37,48] | |
| Ethnicity (%) | White | 333 (94.87) | 566 (92.79) |
| Non-white | 18 (5.13) | 44 (7.21) | |
| Sex (%) | Male | 307 (87.46) | 532 (87.21) |
| Female | 44 (12.54) | 78 (12.79) | |
| Transmission group by sex (%) | MSM | 247 (70.37) | 403 (66.07) |
| HET male | 33 (9.4) | 76 (12.46) | |
| HET female | 31 (8.83) | 50 (8.2) | |
| PWID male | 22 (6.27) | 37 (6.07) | |
| PWID female | 8 (2.28) | 20 (3.28) | |
| Other male | 6 (1.71) | 17 (2.79) | |
| Other female | 4 (1.14) | 7 (1.15) | |
| Time of untreated HIV-1 infection, in years (%) | <1 | 43 (12.25) | 100 (16.39) |
| 1–3 | 51 (14.53) | 82 (13.44) | |
| 3–5 | 90 (25.64) | 150 (24.59) | |
| 5–7 | 61 (17.38) | 104 (17.05) | |
| >7 | 106 (30.2) | 174 (28.52) | |
| Time on ART at first HIV-1 DNA sample, in years (median [IQR]) | 1.5 [1.3,1.7] | 1.5 [1.3–1.7] | |
| Time from ART initiation to below <50 HIV-1 RNA copies/ml, in years (median [IQR]) | 0.3 [0.2,0.5] | 0.3 [0.2,0.5] | |
| CD4+ cell count pre-ART/μl blood (median [IQR]) | 215 [130, 286] | 214 [123, 299] | |
| log 10 HIV-1 plasma RNA pre-ART/ml plasma (median [IQR]) | 5.0 [4.5, 5.4] | 4.9 [4.4,5.4] | |
| HIV-1 RNA (180 days after ART initiation - 1st HIV-1 DNA sample) (%) | <50 copies/ml | 273 (77.78) | 472 (77.38) |
| Viral blips | 48 (13.68) | 82 (13.44) | |
| Low level viremia | 27 (7.69) | 53 (8.69) | |
| HIV-1 RNA (1st - 3rd HIV-1 DNA sample) (%) | <50 copies/ml | 232 (66.1) | 407 (66.72) |
| Viral blips | 88 (25.07) | 154 (25.25) | |
| Low level viremia | 31 (8.83) | 49 (8.03) | |
Patient characteristics in population A (with available viral near full-length NGS sequences obtained from HIV-1 plasma RNA) and population B (with available partial pol Sanger sequences obtained from HIV-1 plasma RNA).
The time of untreated HIV-1 infection was calculated using the estimated HIV-1 infection dates. Pre-ART log10 HIV-1 RNA copies/ml plasma and pre-ART CD4+ cell count/μl blood refer to the last laboratory values available before initiation of ART. Transmission group stratified by sex indicates the self-reported route of infection (men who have sex with men (MSM), heterosexual (HET), people who inject drugs (PWID), and other (including unknown, transfusions, and perinatal transmission)).