. 2020 Nov 2;10:18859. doi: 10.1038/s41598-020-75244-w

Table 2.

Antifungal activity (MIC and MLC) of Thymus albicans essential oil and its major compounds (1,8-cineole, linalool, borneol and α-terpineol) against collection type and clinical strains of Candida, Cryptococcus neoformans, dermatophytes and Aspergillus.

Strains	Thymus albicans		1,8-Cineole		Linalool		Borneol		α-Terpineol
Strains	MIC^a	MLC^a	MIC^a	MLC^a	MIC^a	MLC^a	MIC^a	MLC^a	MIC^a	MLC^a
Candida albicans ATCC 10231	1.25	2.5	10	10	5	5	2.5	> 20	1.25	2.5
Candida tropicalis ATCC 13803	2.5	2.5	20	20	5	5	2.5	> 20	1.25	2.5
Candida krusei H9	2.5	2.5	10	10	10	10	5	> 20	1.25	2.5
Candida guilliermondii MAT23	1.25	1.25	10	10	5	10	2.5	2.5	1.25	1.25–2.5
Candida parapsilosis ATCC 90,018	2.5	2.5	10	10	10	10	5	> 20	0.64–1.25	2.5
Cryptococcus neoformans CECT 1078	1.25	1.25	5–10	10	5	5	1.25	1.25	0.64–1.25	1.25
Epidermophyton floccosum FF9	0.64	0.64	5	5	1.25–2.5	2.5	2.5	2.5	1.25	1.25
Microsporum canis FF1	1.25	1.25	5	5	2.5	2.5	2.5	2.5	1.25	1.25
Microsporum gypseum CECT 2908	1.25	1.25	5–10	10	1.25–2.5	2.5	2.5	2.5	1.25	1.25
Trichophyton mentagrophytes FF7	1.25	1.25	5	5	1.25	2.5	2.5	5	1.25	2.5
Trichophyton mentagrophytes var. interdigitale CECT 2958	1.25	1.25	10	10	2.5	2.5–5	2.5	5	0.64	1.25
Trichophyton rubrum CECT 2794	0.64	0.64	2.5–5	5	1.25	1.25–2.5	2.5	2.5	1.25	1.25–2.5
Trichophyton verrucosum CECT 2992	1.25	1.25	10	10–20	1.25–2.5	1.25–2.5	2.5	2.5	0.64	1.25
Aspergillus niger ATCC 16404	2.5	10–20	10	> 20	5	≥ 20	5	> 20	0.64	10–20
Aspergillus fumigatus ATCC 46645	2.5	5	10	10–20	2.5	20	2.5	> 20	0.32–0.64	2.5
Aspergillus flavus F44	5	5–10	20	20	10	≥ 20	5	> 20	0.64–1.25	2.5

^aMIC and MLC determined by macrodilution method and expressed as μL/mL.