Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 2;10:18801. doi: 10.1038/s41598-020-75903-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of regional toxin application on sympathetic nerve fiber density. (A,B) Whole-heart labeling of tyrosine hydroxylase (TH) demonstrates fewer visible sympathetic nerve fibers on the anterior surface (where toxin solution is applied) of the DBH-Sap heart (B) compared to control (A). (C,D) The posterior surface is similar between control and DBH-Sap groups. (E,F) Short axis TH images of the anterior (E) and posterior (F) surface of a DBH-Sap mouse heart. (G,H) Sympathetic nerve fiber density from anterior base (G) and apex (H) regions 5 days after treatment. At the apex, the percent TH + area was significantly reduced in the epicardium of the DBH-Sap group, and there was also a main effect between groups (***p < 0.001, main effect control vs. DBH-Sap, two-way ANOVA, H). Data are mean ± SD; analyzed with GraphPad Prism 8.3 (GraphPad Software, San Diego, CA, USA); control: n = 3; DBH-Sap: n = 3; **p < 0.01, ***p < 0.001.