Table 1.

Summary of preclinical studies of acute mechanical left ventricular support devices to reduce infarct size

Animal Model	Year	Duration of Ischemia (min)	Duration of Reperfusion (min)	Mechanical Support Before or After Reperfusion	Occluded Vessel	Method of Occlusion	Device	Reduction in Infarct Size?	Reference
Canine	1978	480	X	Before	LAD	Ligation	IABP	Yes	Roberts & Gay [6]
Baboons	1979	1440	X	Before	LAD	Ligation	IABP	No	Haston & McNamara [7]
Porcine	1980	1440	X	Before	LAD	Ligation	IABP	No	Laas & Replogle [8]
Porcine	2008	60	240	Before vs After	LAD	Ligation	IABP	Yes / No	Ledoux & Smalling [9]
Canine	1983	240	X	Before	LAD	Ligation	LA-FA Bypass	Yes	Catinella & Spencer [12]
Porcine	2013	120	120	Before	LAD	Balloon angioplasty	TandemHeart	Yes	Kapur & Karas [13]
Canine	1989	120	60	Before	LAD	Ligation	Hemopump	Yes	Merhige & Wampler [14]
Canine	1992	120	60	Before	LAD	Snare ligation	Hemopump/IABP	Yes	Smalling & Amirian [15]
Canine	2005	120	240	Before vs After	LAD	Snare ligation	Hemopump	Yes / No	Achour & Smalling [16]
Sheep	2003	60	120	Before vs After	LAD	Ligation	Impella 5.0	Yes	Meyns & Flameng [17]
Porcine	2015	90	120	Before	LAD	Balloon angioplasty	Impella CP	Yes	Kapur & Karas [18]
Porcine	2015	120	120	Before	LCx	Ligation	Impella LD	Yes	Sun & Wang [20]
Porcine	2018	90	120	Before	LAD	Balloon angioplasty	Impella CP	Yes	Esposito & Kapur [21]