Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 1;34(21-22):1439–1451. doi: 10.1101/gad.343186.120

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Tiwari et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 5. — De novo rearrangements detected after p53 loss are associated with retroelements. (A) Circos plot of genomic rearrangements in A375 cells. Genomic rearrangements emerging after p53 loss are indicated (red lines) along with pre-existing rearrangements in the parental A375 cell line (gray lines). Repeat element proximity is indicated by red tiles (outer gray ring) along with annotations for rearrangement junctions (inner gray ring). (B) Genomic rearrangements occur at repeat elements in p53 knockout (n = 9 of 18 breakpoints) but not wild-type (n = 0 of 26 breakpoints) cells. (C) p53 knockout associated genomic rearrangements are commonly associated with LINE and SINE (n = 8 of 18 breakpoints), but not LTR or DNA repeat elements (n = 1 of 18 breakpoints).